As a "Memory Medic" committed to helping people
improve their learning and memory capabilities, I am often asked in the on-line
Quora.com forum questions like: "How can I make myself smarter?" I am
stunned to see so many people struggling in school or the workplace who
perceive a need to become smarter. Nobody seems to know how to become smarter.
In fact, it is commonly believed that you cannot change your IQ, that you are
stuck with whatever level you happen to have. This belief is wrong.
Experimental evidence demonstrates that IQ often improves with age as infants
progress through elementary school. However, by middle school and later in life
IQ seems to become fixed in
most people. As far as I know, there has been
little research to test this assumption. Even so, in my own experience, and
others have similarly reported, going through a rigorous Ph.D. program does
make you smarter. I think other things can work too.
I became sensitized to this point when I was in Graduate
school at Notre Dame. I barely gained admission, because my test scores did not
match their usual acceptance criteria. My major professor chastised me on
multiple occasions for not being smart enough, with the comment, "Strive for
insight." If I was short on insight
capability, it meant that I am not smart enough to be at Notre Dame as his
student. I believed that at first. After all, my IQ score, determined in middle
school, was 113, only a little above average and certainly not up to the level
of Notre Dame Ph.D. graduate students. Yet my professor was also telling me
that I could make myself smarter. Otherwise, what’s the point of “striving?” He
couldn’t explain how to become smarter, but no doubt he had discovered this was
possible from his own experience as he progressed through the rigorous
education of becoming a Notre Dame priest and a earning a science Ph.D. in a
prestigious University of Chicago program.
Eventually, I learned he was right on both counts: I was not
smart enough, but by striving for insightfulness, I could make myself smarter.
Eventually, I think I figured out how to become smarter. I know my IQ is higher
now, even in old age, than it was when I was 13. I don't know how high, and don't care to
know. What matters is that I found what works for me to become smarter. I think
I can explain some of that to students.
School lessons can be intimidating and sometimes “over the
head” of many students. Students get discouraged when they don't understand
things. When they don't understand, they struggle, and their grades suffer.
They come to believe they are not smart. They may quit trying, because they
wrongly conclude they don't have the ability. They become underachievers. Their
belief in their incompetence becomes a self-fulfilling prophecy.
I recently took on a task of writing a curricular item for
science teaching of eighth graders. The curricular item I was writing involved
a "Simulated Peer Review" learning activity in which middle-school
groups work together to role play being peer reviewers of a scientific research
report. I give them scaffolding questions to show them what to check for, and I
also totally reconstruct the report so it could be understood by middle
schoolers. The published research paper I needed to re-write posed a major
problem: it was so complex that even I didn’t understand it.
Figure 1. Diagram in the original research report used to explain the purpose of the study and how it was done. Original legend presented the full chemical names. From Guedes et al. 2018.
This paper was a report on drug
development for pain relief. The paper was ideal for a variety of reasons, but it
was unbelievably complex, with lots of chemistry and arcane acronyms, as
illustrated in Figure 1. In figuring this out, I reminded myself how I was
going about this task, which crystallized as five steps or principles that anyone
can use to figure out most anything, and in the process develop the mental
algorithms that will make you smarter.
How am I supposed to explain the ideas in this figure to 8th
graders? The legend explaining all these abbreviations and relationships only
made things still harder to comprehend. Here maybe was a chance to track my
strategy for figuring things out, and I could formulate and explain simple
steps that would be generally applicable. I kept track of the sequence of the
steps I used, and now I can specify a specific sequence of tactics for
developing understanding.
Step 1. Believe You Can Become
Smarter. When I formulated the "Learning Skills Cycle" in
a book I recently wrote for teachers and parents, the very first step in that
cycle was "Motivation." A learner who is not motivated to learn will
not make the effort needed to learn much. They become under-achievers. If you
don't believe you can become smarter, you won't be motivated to “strive for
insight.”
Step 2. Look for the Big Picture. Look
first for over-all patterns. The original legend of Fig. 1 explained in an overly complicated way that
damage to cell membranes triggers three chains of chemical reactions that stem
from breakdown of the phospholipids that form cell membranes. Think about the
purpose of the diagram: the three pathways may reveal points in the pathways
where a drug might alter the response to pain. The pathway on the right
is not very relevant, so you don’t have to think about it. Focus on the meaning
of the other two paths.
T
he
breakdown products of these membrane phospholipids, as explained in the original
legend, included three relevant enzymes (COX, Cyp450, and sEH), and a host of
chemicals, some of which cause inflammation and pain. The figure also indicates
that enzymes are targets: anything that inhibits them would stop their action.
Note the diagram shows inhibition with lines that end in a line segment instead
of an arrow. We see that inhibition of only one target enzyme, COX, can help to
alleviate pain (such inhibitors are already in medical use). In the other pathway,
the so-called epoxy fatty acids (EpFAs) could, in theory, block the COX enzyme
or have a direct inhibitory effect on inflammation and pain. However, the EpFAs
are destroyed by the enzyme soluble epoxy hydrolase (sHE), so they are not
available for pain relief. Note, however, that a second enzyme (sEH), if it
could be inhibited by the drug t-TUCB, it would stop the destruction of EpFAs,
enabling them to accumulate and exert their anti-inflammatory and pain
relieving effects. This is the purpose of the study, that is, to test to see if
t-TUCB can actually reduce pain, as a previous study had suggested.
3. Simplify. For thinking
purposes, temporarily strip out the information that is non essential. Be discerning in what you temporarily omit from your
thinking. Sometimes, small items of information (as the three lines that end in
line segments) are crucial for understanding. The other key elements here are
the two over-all pathways, the three enzymes they contain, and the steps in the
path they i
inhibit.
For
the moment, I can ignore most of the names of the compounds. They just clutter
my mind with more information than I can hold in working memory to think with.
I can also ignore for now the genetic mechanisms, which though important, are
not central to the purpose of this present report. Likewise, I can also ignore
the glucocorticoid inhibition of enzymes that break down membrane
phospholipids, because these enzymes are blocked by drugs like cortisone.
The
reason we need to simplify is that we think with the information that we can
hold in conscious working memory (as when you try to remember a phone number
you just looked up). The capacity of working memory is very limited (4-7 items
at any one time). Thus, to think clearly about any confusing matter, you must
not clutter your mind with more information at any one time than your working
memory can handle.
|
Figure 2. Simplification of Fig. 1 |
Step 4. Reframe the
Issue. Einstein
was famous for reframing his problems in the form of thought experiments, such
was watching movement of trains relative to each other or riding on a moonbeam.
We don’t have to be as imaginative as Einstein. In this example, all we have to
do is re-draw the diagram in a form that captures the essence of the key
information. So, to help my understanding,
I sketched a simpler diagram that captures the big picture" in the
simplest possible way (Fig. 2). Note that I gave blue color to emphasize the
enzymes and red lines to indicate their inhibition. Two inhibitory influences
were shown with dashes to emphasize that this was only theoretical, because the
anti-inflammatory chemicals in the right-hand path are usually destroyed and
thus not available or inhibition. The test drug had been shown earlier to
inhibit the enzyme in the right-hand pathway. What we don’t know is if this
drug actually reduces pain. Now I have the ideas framed in the most meaningful
and distinct ways. At this point, I could see the crucial points, unobscured by
all the detail.
Step 5. Identify the Crucial Details.
The first objective is to understand the principles, and then add in
whatever level of detail that is necessary. No more, no less. One of my
cardinal principles of learning is flagged with the question: What is the point
of learning if you don't remember it? In this particular case, learners need to
put back into those details that are crucial and may have practical relevance.
As I show in Figure 3, students can now see that a drug that inhibits COX could
alleviate pain, as could any new drug that could inhibit sHE (soluble epoxy
hydrolase) by preventing destruction of the anti-inflammatory epoxy fatty acids.
Counteracting the inflammatory chemicals (prostaglandins) would also alleviate
pain, and this is what many known pain relievers do. At this point, I
understand the principles of pain biochemistry, and I bet 8th graders can do so
too, even if they haven’t yet learned chemistry.
|
Figure 3. Essential detail reinserted into Fig. 2 |
This reminds me to tell you that
in my Learning Skills Cycle, I always put the "Understand" step
before the "Memorize" step. Two reasons explain why: 1) understanding
allows you to simplify and reduce the amount of detail that will burden your
memory, and 2) the very act of striving for the insight about the issues is
helping to encode the relevant information and is rehearsal practice that will
help consolidate the memory into long-lasting memory. Thinking, rather than
rote repetition, is the most powerful way to memorize.
We have now arrived at the
final and most practical stage in the Learning Skills Cycle, namely, Problem Solving
and Creativity. Now we can get to the practical matter of using this new
understanding to plan the exploration to find drugs that can alleviate
inflammation and pain. Drugs that block the path on the left should reduce pain,
and this is the mechanism of action of aspirin, Tylenol, and other
non-steroidal drugs. In theory, we could alleviate pain by preventing the destruction
of anti-inflammatory epoxy fatty acids by blocking the enzyme (sEH) that
destroys them. Epoxy hydrolase is a new target for drug development, which the
research paper I was rewriting aimed to test with an inhibitor of this enzyme.
I invite you to join my LinkedIn group on
"Neuroeducation: Promoting Cognitive Development"
Sources:
Guedes, A. G. P. et al.
(2018). Pharmacokinetics and antinociceptive effects of the soluble epoxide
hydrolase inhibitor t -TUCB in horses with experimentally induced radiocarpal
synovitis. J. Veterinary Pharmacology
and Therapeutics 2018, 41 (2) , 230-238. DOI: 10.1111/jvp.12463.
Klemm, W. R. 2017. The
Learning Skills Cycle. A way to Rethink Education Reform. Lanham, Maryland:
Rowman& Littlefield. Lanham, Md., Rowman & Littlefield.
Klemm, W. R. 2013. Teaching
beginning college students with adapted published research reports. J.
Effective Teaching. 13 (2), 6-20.