Teenage Angst Is Bad for the Brain

Remember being a teenager? ... and all the stress of boy-girl problems, over-bearing parent problems, bullies, worries about school and your future, and frustrated attempts to be popular? Scientists have long known that chronic stress can kill nerve cells. Now it seems that an especially vulnerable time is adolescence. It now seems clear that the brain is being re-built during teenage.

Read all about it at my memory improvement Web site. Click here. Follow the link to the "Emotions" category.

Remembering Names and Faces

Everybody has trouble remembering names and faces. The usual tricks don't always work, and may even be counter-productive. I have just posted a summary of a study that challenges the conventional approach to remembering names and faces. Click here for details.

More confirmation of sleep loss impairment of memory

I just wrote a summary of yet another study which showed that missing one night's sleep impairs memory of what happened the next day, even though the sleep loss was made up later. The test conditions involved losing sleep on one night, then learning stuff on the next day, followed by a normal night's sleep, and then being tested the next day. So this indicates that this is a "proactive" effect, where sleep loss before learning impairs learning. I have reviewed other studies that show impairment when sleep loss occurs at the same time as learning, as in cramming for exams. Click here for details.

Multi-tasking is the Wrong Way to Learn

Today's kids are in to multi-tasking. This is the generation hooked on iPods, IM'ing, video games - not to mention TV! According to a Kaiser Family Foundation study last year, school kids in all grades beyond the second grade committed, on average, more than six hours per day to TV or videos, music, video games, and computers. Almost one-third reported that "most of the time" they did their homework while chatting on the phone, surfing the Web, sending instant messages, watching TV, or listening to music.Kids think that this entertainment while studying helps their learning. It probably does make learning less tedious, but it clearly makes learning less efficient and less effective. Multi-tasking violates everything we know about how memory works. Now we have objective scientific evidence that multi-tasking impairs learning. See the summary at my Web site.

Distractability increases with age

Filtering out irrelevant stimuli is done more easily when you are young than when you are old. This has profound implications for age-related decline in memory ability. Read about what you can do to compensate at my Web-site discussion of recent research on this matter.
Click here.

And don't forget to get my book, so you can put all this in context and actually improve your memory - not just compensate for age-related decline.

New Treatment for Post-traumatic Stress Syndrome

If you saw the Nov. 26, 2006 edition of "60 Minutes" on TV, you learned about a promising new treatment, and sometimes cure, for post-traumatic stress disorder (PTSD). Actually, I discussed many of these ideas in my memory-improvement book and posted an explanation of this specific idea months ago on my Web site, and I have now updated it to report that physicians have actually embraced the findings of memory research and shown that treatment with a common blood-pressure drug, propranolol, can have strikingly beneficial results on PTSD.

See the latest update at my Web site. Locate "Medical Issues" on the Contents page and click on the item involving PTSD.

Social Networks Provide "Protective Reserve" for Alzheimer's Disease

In an earlier posting, I reviewed a study that showed that staying mentally active can help some people to protect against development of symptoms of Alzheimer's disease, even when some brain lesions of the disease are present. The usual explanation is that a lifetime of high mental activity creates a kind of protective reserve. Now another study reveals that close contact with friends, relatives and social networks can offer a similar protective-reserve effect. Check the "Medical Issues" section of my Web site's summaries of memory research. Click here.

Gene therapy helps memory

A new research report just out shows that gene therapy, targeted against stress hormones, helps memory. As I explain in my book, stress hormones are bad for memory.

Here is the press release:


Contact: Mark Shwartz
mshwartz@stanford.edu
650-723-9296
Stanford University

Scientists use gene therapy to improve memory and learning in animals

Stanford University neuroscientists have designed a gene that enhances memory and learning ability in animals under stress. Writing in the Nov. 8 issue of the Journal of Neuroscience, the Stanford team says that the experimental technique might one day lead to new forms of gene therapy that can reduce the severe neurological side effects of steroids, which are prescribed to millions of patients with arthritis, asthma and other illnesses.

"Steroids can mess up the part of the brain involved in judgment and cognition," said neuroendocrinologist Robert Sapolsky, co-author of the study. "In extreme cases it's called steroid dementia. Ideally, if you could deliver this gene safely, it would protect the person from some of these cognitive side effects, while allowing the steroid to do whatever helpful thing it should be doing elsewhere in the body."

Sapolsky, the John A. and Cynthia Fry Gunn Professor of Biological Sciences and a professor of neurology and neurological sciences at Stanford, has conducted numerous experiments on the damaging physiological effects of stress and has written extensively on the subject, including a 1995 book, "Why Zebras Don't Get Ulcers."

Hormonal effects

In the Journal of Neuroscience study, Sapolsky and his colleagues focused on the effect of stress on the hippocampus, a part of the brain that's important for learning and memory. Nerve cells throughout the hippocampus contain numerous receptors that respond to a group of steroid hormone called glucocorticoids, which are secreted from the adrenal glands in male and female rats during times of stress. When high levels of these corticoids bind to the hippocampal receptors, they can trigger a destructive biochemical cascade that damages nerve cells in the hippocampus and ultimately impairs memory and learning.

But not all hormones are bad. Estrogen, the primary female sex hormone, enhances memory and can therefore block the negative cognitive effects of the corticoids.

"Estrogen protects memory against stress," said former Stanford postdoctoral fellow Andrea Nicholas, lead author of the study, who was recently named an adjunct professor at St. Mary's College. "In women, there are long-term protective effects of estrogen in the brain. As people age, females often fare better than males cognitively, in part because they have that estrogenic protection."

In a 2004 study, Sapolsky and his co-workers showed that gene therapy could be used to neutralize the deleterious effects of stress in laboratory rats. The idea behind gene therapy is eventually to cure a disease or repair an injury by injecting a beneficial gene into the patient's DNA. For the experiment, Sapolsky and his team created what geneticists call a chimera--an experimental strand of DNA made with two genes stitched together, in this case a glucocorticoid-receptor gene from a rat combined with an estrogen-receptor gene from a human.

When this new chimeric gene was injected into the hippocampus of a rat, the result was dramatic. The gene produced new protein receptors that quickly converted stress-inducing glucocorticoids into beneficial estrogen signals.